The diversity of experimental systems used to study the effects of Notch signaling, pleiotropy of Notch signals, and increased appreciation of Notch involvement in disease has made the “Notch field” explode in the past decade.  In 2007 we launched a biennial general Notch research meeting that aims to reflect the diversity of Notch research and bring together researchers from different fields and different experimental systems interested in Notch signaling. This first meeting was a thunderous success and confirmed our belief that such a regular meeting will allow each of us to become better informed about what is happening in spheres of interest not immediately connected with our own, get a feeling about the trends and most exciting developments in the field, explore medical Notch applications, and hear and meet old and new players.  Interspersed with these general meetings, in alternating years, more focused smaller workshops will help to explore specific thematic in more depth. The first such workshop with the title “Notch and Cancer” was held in 2008.

These meetings are sponsored by Fondation Santé and benefit from the generosity of additional sponsors. For the registration form please visit the conference website www.TheNotchMeeting.org.

Organizing Committee

Iannis Aifantis, New York University (NYU), USA; Spyros Artavanis-Tsakonas, Harvard Medical School, USA; Doug Barrick, The John Hopkins University, USA; Anna Bigas, IMIM-Hospital del Mar, PRBB, Spain; Stephen Blacklow, Brigham & Women's Hospital, Harvard Medical School, USA; Sarah Bray, University of Cambridge, UK; Tony Capobianco, University of Florida, USA; Christos Delidakis, Institute of Molecular Biology and Biotechnology, Greece; Mark Fortini, Thomas Jefferson University, USA; Anne Hart, MGH & Harvard Medical School, USA; Tasuko Honjo, Kyoto University Graduate School of Medicine, Japan; Alain Israel, Institut Pasteur, Paris, France; Ryoichiro Kageyama, Institute for Virus Research, Kyoto University, Japan; Thomas Klein, University of Cologne, Institute of Genetics, Germany; Raphael Kopan, Washington University, School of Medicine, USA; Urban Lendahl, Karolinska Institute, Sweden; Angeliki Louvi, Yale University, School of Medicine, USA; Kenji Matsuno, Tokyo University of Science, Japan; Lucio Miele, Loyola University Chicago, USA; Marco Milan, IRB Barcelona, Spain; Benjamin Ohlstein, Columbia University Medical Center, USA; Barbara Osborne, University of Massachusetts, USA; Isabella Screpanti, University "La Sapienza", Italy; Gerry Weinmaster, David Geffen School of Medicine at UCLA, USA.

Venue

The meeting was held in Athens, Greece at the National Bank of Greece’s Karatzas Auditorium at 86 Aiolou Street. 

Program

The conference was divided into the different sessions listed below:

• Molecular Aspects of Signaling
• Structural Studies, Biochemistry
• Developmental Regulation, Cell Fates in Specific Systems
• Notch Immunology
• Notch Signal Integration: Crosstalk, Genetic Circuitries
• Notch Diseases and Notch Disease Models
• Oncogenesis, Cell Proliferation
• Notch Disease Targets and Therapeutic Approaches: Translational Biology/Drug Development
• Notch Trafficking: A day devoted to the cellular trafficking of Notch receptor and its ligands